View source for Inter-alpha-inhibitor (FXIIIa)

{| class="toccolours" border="1" style="float: left; clear: right; margin: 0 0 1em 1em; border-collapse: collapse;"
! {infobox header}| '''{{PAGENAME}}''' 
|-
| Substrate peptide name
| {{PAGENAME}}
|-
| Synonyms
|  Inter-alpha-trypsin inhibitor
|-
| Determination type
| In vitro 
|-
| Source
| Homo sapiens
|-
| Subcellular localization
|Extracellular space
|-
| Swissprot ID
| [http://au.expasy.org/uniprot/P19827 P19827 - HC1]
[http://au.expasy.org/uniprot/P19823 P19823 - HC2]

[http://au.expasy.org/uniprot/O43291 O43291 - bikunin]
|-
| Reactive glutamines
|HC1 - Q8
HC2 - Q90, Q204, Q299, Q315, Q420, Q426, Q431, Q438

Bikunin - Q74
|-
| Reactive lysines
| -
|-
| Substrate sequence
|''Q''AVDTA
ALA''Q''AR	

PTVAQ''Q''R
	
VIDFN''Q''NIR
	
T''Q''VADAK
	
NHGIA''Q''R	

IYGN''Q''DTSS''Q''LK	
		
FYN''Q''CSTPLLR
	
ECL''Q''TCR	
|-
| Structure
| [http://www.rcsb.org/pdb/explore/explore.do?structureId=1BIK 1BIK]
|-
| Surface accessibility
|
|-
| Disorder prediction
| [http://iupred.enzim.hu/index.html IUPred]
|-
| Reference
| [http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&list_uids=21939789&dopt=Abstract PMID:21939789]
|-
| Notes
| Inter-α-inhibitor is cross-linked to the fibrin clot in a 1:20 ratio relative to the known 
factor XIIIa substrate α2-antiplasmin. This interaction may protect fibrin or other Lys-donating
 
proteins from adventitious proteolysis by increasing the local concentration of bikunin. 
|-
| {infobox header} | 
|-
|}

[[Category:FXIIIa|*]]