Inter-alpha-inhibitor - Revision history

Bernadett at 11:46, 10 March 2015

2015-03-10T11:46:07Z

WikiSysop at 09:05, 28 September 2011

2011-09-28T09:05:40Z

WikiSysop at 09:05, 28 September 2011

2011-09-28T09:05:24Z

WikiSysop at 09:04, 28 September 2011

2011-09-28T09:04:53Z

WikiSysop at 09:03, 28 September 2011

2011-09-28T09:03:30Z

WikiSysop at 09:03, 28 September 2011

2011-09-28T09:03:16Z

WikiSysop at 09:02, 28 September 2011

2011-09-28T09:02:50Z

WikiSysop at 09:01, 28 September 2011

2011-09-28T09:01:05Z

WikiSysop at 09:00, 28 September 2011

2011-09-28T09:00:35Z

WikiSysop: Created page with "{| class="toccolours" border="1" style="float: left; clear: right; margin: 0 0 1em 1em; border-collapse: collapse;" ! {{infobox header}}| '''{{PAGENAME}}''' |- | Substrate pepti..."

2011-09-28T09:00:03Z

Created page with "{| class="toccolours" border="1" style="float: left; clear: right; margin: 0 0 1em 1em; border-collapse: collapse;" ! {{infobox header}}| '''{{PAGENAME}}''' |- | Substrate pepti..."

New page

{| class="toccolours" border="1" style="float: left; clear: right; margin: 0 0 1em 1em; border-collapse: collapse;"
! {{infobox header}}| '''{{PAGENAME}}'''
|-
| Substrate peptide name
| {{PAGENAME}}
|-
| Synonyms
| Inter-alpha-trypsin inhibitor
|-
| Determination type
| In vitro
|-
| Source
| Homo sapiens
|-
| Subcellular localization
|Extracellular space
|-
| Swissprot ID
| [http://au.expasy.org/uniprot/P19827 P19827 - HC1]
[http://au.expasy.org/uniprot/P19823 P19823 - HC2]
[http://au.expasy.org/uniprot/O43291 O43291 - bikunin]
|-
| Reactive glutamines
|HC1 - Q8, Q319, Q468
HC2 - Q90, Q203, Q204, Q299, Q315, Q420, Q431, Q438
Bikunin - Q74
|-
| Reactive lysines
| -
|-
| Substrate sequence
|'Q'AVDTAVDGVFIR
GSLVQASEANL'Q'AAQDFVR
'Q'YYEGSEIVVAGR
ALA'Q'AR
AHVSFKPTVA'QQ'R
AEDHFSVIDFN'Q'NIR
T'Q'VADAKR
LSNENHGIA'Q'R
IYGNQDTSS'Q'LK
FYN'Q'CSTPLLR
ECL'Q'TCR
|-
| Structure
| [http://www.rcsb.org/pdb/explore/explore.do?structureId=1BIK 1BIK]
|-
| Surface accessibility
|
|-
| Disorder prediction
| [http://iupred.enzim.hu/index.html IUPred]
|-
| Reference
| [http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&list_uids=21939789&dopt=Abstract PMID:21939789]
|-
| Notes
| Inter-α-inhibitor is cross-linked to the fibrin clot in a 1:20 ratio relative to the known factor XIIIa substrate α2-antiplasmin. This interaction may protect fibrin or other Lys-donating proteins from adventitious proteolysis by increasing the local concentration of bikunin.
|-
| {{infobox header}} |
|-
|}

[[Category:Tissue transglutaminase|*]]

@@ Line 35: / Line 35: @@
 |''Q''AVDTA
 SEANL''Q''AAQDF
 ''Q''YYEGS
@@ Line 66: / Line 67: @@
 |-
 | Notes
-| Inter-α-inhibitor is cross-linked to the fibrin clot in a 1:20 ratio relative to the known factor XIIIa substrate α2-antiplasmin. This interaction may protect fibrin or other Lys-donating proteins from adventitious proteolysis by increasing the local concentration of bikunin.
+| Inter-α-inhibitor is cross-linked to the fibrin clot in a 1:20 ratio relative to the known
 |-
 | {{infobox header}} |

@@ Line 33: / Line 33: @@
 |-
 | Substrate sequence
-|''Q''AVDTA
+|'''Q'''AVDTA
 SEANL"Q"AAQDF
 'Q'YYEGS

@@ Line 33: / Line 33: @@
 |-
 | Substrate sequence
-|"Q"AVDTA
+|''Q''AVDTA
 SEANL"Q"AAQDF
 'Q'YYEGS

@@ Line 1: / Line 1: @@
 {| class="toccolours" border="1" style="float: left; clear: right; margin: 0 0 1em 1em; border-collapse: collapse;"
-! {{infobox header}}| '''{{PAGENAME}}'''
+! {infobox header}| '''{{PAGENAME}}'''
 |-
 | Substrate peptide name
@@ Line 72: / Line 72: @@
 proteins from adventitious proteolysis by increasing the local concentration of bikunin.
 |-
-| {{infobox header}} |
+| {infobox header} |
 |-
 |}
 [[Category:Tissue transglutaminase|*]]

@@ Line 33: / Line 33: @@
 |-
 | Substrate sequence
-|'''Q'''AVDTA
+|''Q''AVDTA
-SEANL"Q"AAQDF
+SEANL''Q''AAQDF
-'Q'YYEGS
+''Q''YYEGS
 ALA'Q'AR
-KPTVA'QQ'R
+ALA''Q''AR
 VIDFN'Q'NIR
-T'Q'VADAK
+KPTVA''QQ''R
 NHGIA'Q'R
-QDTSS'Q'LK
+VIDFN''Q''NIR
 FYN'Q'CSTPLLR
-ECL'Q'TCR
+T''Q''VADAK
 |-
 | Structure

@@ Line 36: / Line 36: @@
 GSLVQASEANL'Q'AAQDFVR
 'Q'YYEGSEIVVAGR
- ALA'Q'AR
+ALA'Q'AR
 AHVSFKPTVA'QQ'R
 AEDHFSVIDFN'Q'NIR

@@ Line 20: / Line 20: @@
 | [http://au.expasy.org/uniprot/P19827 P19827 - HC1]
 [http://au.expasy.org/uniprot/P19823 P19823 - HC2]
 [http://au.expasy.org/uniprot/O43291 O43291 - bikunin]
 |-
@@ Line 25: / Line 26: @@
 |HC1 - Q8, Q319, Q468
 HC2 - Q90, Q203, Q204, Q299, Q315, Q420, Q431, Q438
 Bikunin - Q74
 |-