Difference between revisions of "Inter-alpha-inhibitor"
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GSLVQASEANL'Q'AAQDFVR | GSLVQASEANL'Q'AAQDFVR | ||
'Q'YYEGSEIVVAGR | 'Q'YYEGSEIVVAGR | ||
| − | + | ALA'Q'AR | |
AHVSFKPTVA'QQ'R | AHVSFKPTVA'QQ'R | ||
AEDHFSVIDFN'Q'NIR | AEDHFSVIDFN'Q'NIR | ||
Revision as of 09:01, 28 September 2011
| Template:Infobox header| Inter-alpha-inhibitor | |
|---|---|
| Substrate peptide name | Inter-alpha-inhibitor |
| Synonyms | Inter-alpha-trypsin inhibitor |
| Determination type | In vitro |
| Source | Homo sapiens |
| Subcellular localization | Extracellular space |
| Swissprot ID | P19827 - HC1 |
| Reactive glutamines | HC1 - Q8, Q319, Q468
HC2 - Q90, Q203, Q204, Q299, Q315, Q420, Q431, Q438 Bikunin - Q74 |
| Reactive lysines | - |
| Substrate sequence | 'Q'AVDTAVDGVFIR
GSLVQASEANL'Q'AAQDFVR 'Q'YYEGSEIVVAGR ALA'Q'AR AHVSFKPTVA'QQ'R AEDHFSVIDFN'Q'NIR T'Q'VADAKR LSNENHGIA'Q'R IYGNQDTSS'Q'LK FYN'Q'CSTPLLR ECL'Q'TCR |
| Structure | 1BIK |
| Surface accessibility | |
| Disorder prediction | IUPred |
| Reference | PMID:21939789 |
| Notes | Inter-α-inhibitor is cross-linked to the fibrin clot in a 1:20 ratio relative to the known factor XIIIa substrate α2-antiplasmin. This interaction may protect fibrin or other Lys-donating proteins from adventitious proteolysis by increasing the local concentration of bikunin. |
| Template:Infobox header | |
