Difference between revisions of "Inter-alpha-inhibitor"
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| Substrate sequence | | Substrate sequence | ||
| − | | | + | |''Q''AVDTA |
| − | SEANL | + | SEANL''Q''AAQDF |
| − | 'Q'YYEGS | + | ''Q''YYEGS |
| − | ALA'Q'AR | + | |
| − | KPTVA'QQ'R | + | ALA''Q''AR |
| − | VIDFN'Q'NIR | + | |
| − | T'Q'VADAK | + | KPTVA''QQ''R |
| − | NHGIA'Q'R | + | |
| − | QDTSS'Q'LK | + | VIDFN''Q''NIR |
| − | FYN'Q'CSTPLLR | + | |
| − | ECL'Q'TCR | + | T''Q''VADAK |
| + | |||
| + | NHGIA''Q''R | ||
| + | |||
| + | QDTSS''Q''LK | ||
| + | |||
| + | FYN''Q''CSTPLLR | ||
| + | |||
| + | ECL''Q''TCR | ||
|- | |- | ||
| Structure | | Structure | ||
Revision as of 09:04, 28 September 2011
| Template:Infobox header| Inter-alpha-inhibitor | |
|---|---|
| Substrate peptide name | Inter-alpha-inhibitor |
| Synonyms | Inter-alpha-trypsin inhibitor |
| Determination type | In vitro |
| Source | Homo sapiens |
| Subcellular localization | Extracellular space |
| Swissprot ID | P19827 - HC1 |
| Reactive glutamines | HC1 - Q8, Q319, Q468
HC2 - Q90, Q203, Q204, Q299, Q315, Q420, Q431, Q438 Bikunin - Q74 |
| Reactive lysines | - |
| Substrate sequence | QAVDTA
SEANLQAAQDF QYYEGS ALAQAR KPTVAQQR VIDFNQNIR TQVADAK NHGIAQR QDTSSQLK FYNQCSTPLLR ECLQTCR |
| Structure | 1BIK |
| Surface accessibility | |
| Disorder prediction | IUPred |
| Reference | PMID:21939789 |
| Notes | Inter-α-inhibitor is cross-linked to the fibrin clot in a 1:20 ratio relative to the known factor XIIIa substrate α2-antiplasmin. This interaction may protect fibrin or other Lys-donating proteins from adventitious proteolysis by increasing the local concentration of bikunin. |
| Template:Infobox header | |
