Difference between revisions of "Inter-alpha-inhibitor (FXIIIa)"
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| Substrate peptide name | | Substrate peptide name | ||
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ECL''Q''TCR | ECL''Q''TCR | ||
| − | + | |- | |
| + | | Structure | ||
| + | | [http://www.rcsb.org/pdb/explore/explore.do?structureId=1BIK 1BIK] | ||
| + | |- | ||
| + | | Surface accessibility | ||
| + | | | ||
| + | |- | ||
| + | | Disorder prediction | ||
| + | | [http://iupred.enzim.hu/index.html IUPred] | ||
| + | |- | ||
| + | | Reference | ||
| + | | [http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&list_uids=21939789&dopt=Abstract PMID:21939789] | ||
| + | |- | ||
| + | | Notes | ||
| + | | Inter-α-inhibitor is cross-linked to the fibrin clot in a 1:20 ratio relative to the known | ||
| + | factor XIIIa substrate α2-antiplasmin. This interaction may protect fibrin or other Lys-donating | ||
| + | |||
proteins from adventitious proteolysis by increasing the local concentration of bikunin. | proteins from adventitious proteolysis by increasing the local concentration of bikunin. | ||
|- | |- | ||
| − | | | + | | {infobox header} | |
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|} | |} | ||
[[Category:FXIIIa|*]] | [[Category:FXIIIa|*]] | ||
Latest revision as of 11:11, 10 March 2015
| Inter-alpha-inhibitor (FXIIIa) | |
|---|---|
| Substrate peptide name | Inter-alpha-inhibitor (FXIIIa) |
| Synonyms | Inter-alpha-trypsin inhibitor |
| Determination type | In vitro |
| Source | Homo sapiens |
| Subcellular localization | Extracellular space |
| Swissprot ID | P19827 - HC1 |
| Reactive glutamines | HC1 - Q8
HC2 - Q90, Q204, Q299, Q315, Q420, Q426, Q431, Q438 Bikunin - Q74 |
| Reactive lysines | - |
| Substrate sequence | QAVDTA
ALAQAR PTVAQQR VIDFNQNIR TQVADAK NHGIAQR IYGNQDTSSQLK FYNQCSTPLLR ECLQTCR |
| Structure | 1BIK |
| Surface accessibility | |
| Disorder prediction | IUPred |
| Reference | PMID:21939789 |
| Notes | Inter-α-inhibitor is cross-linked to the fibrin clot in a 1:20 ratio relative to the known
factor XIIIa substrate α2-antiplasmin. This interaction may protect fibrin or other Lys-donating proteins from adventitious proteolysis by increasing the local concentration of bikunin. |
