Difference between revisions of "Inter-alpha-inhibitor"
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| Substrate peptide name | | Substrate peptide name | ||
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| [http://au.expasy.org/uniprot/P19827 P19827 - HC1] | | [http://au.expasy.org/uniprot/P19827 P19827 - HC1] | ||
[http://au.expasy.org/uniprot/P19823 P19823 - HC2] | [http://au.expasy.org/uniprot/P19823 P19823 - HC2] | ||
| + | |||
[http://au.expasy.org/uniprot/O43291 O43291 - bikunin] | [http://au.expasy.org/uniprot/O43291 O43291 - bikunin] | ||
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|HC1 - Q8, Q319, Q468 | |HC1 - Q8, Q319, Q468 | ||
HC2 - Q90, Q203, Q204, Q299, Q315, Q420, Q431, Q438 | HC2 - Q90, Q203, Q204, Q299, Q315, Q420, Q431, Q438 | ||
| + | |||
Bikunin - Q74 | Bikunin - Q74 | ||
|- | |- | ||
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|- | |- | ||
| Substrate sequence | | Substrate sequence | ||
| − | |'Q' | + | |''Q''AVDTA |
| − | + | SEANL''Q''AAQDF | |
| − | 'Q' | + | |
| − | + | ''Q''YYEGS | |
| − | + | ||
| − | + | ALA''Q''AR | |
| − | T'Q' | + | |
| − | + | KPTVA''QQ''R | |
| − | + | ||
| − | FYN'Q'CSTPLLR | + | VIDFN''Q''NIR |
| − | ECL'Q'TCR | + | |
| + | T''Q''VADAK | ||
| + | |||
| + | NHGIA''Q''R | ||
| + | |||
| + | QDTSS''Q''LK | ||
| + | |||
| + | FYN''Q''CSTPLLR | ||
| + | |||
| + | ECL''Q''TCR | ||
|- | |- | ||
| Structure | | Structure | ||
| Line 56: | Line 67: | ||
|- | |- | ||
| Notes | | Notes | ||
| − | | Inter-α-inhibitor is cross-linked to the fibrin clot in a 1:20 ratio relative to the known factor XIIIa substrate α2-antiplasmin. This interaction may protect fibrin or other Lys-donating proteins from adventitious proteolysis by increasing the local concentration of bikunin. | + | | Inter-α-inhibitor is cross-linked to the fibrin clot in a 1:20 ratio relative to the known |
| + | factor XIIIa substrate α2-antiplasmin. This interaction may protect fibrin or other Lys-donating | ||
| + | |||
| + | proteins from adventitious proteolysis by increasing the local concentration of bikunin. | ||
|- | |- | ||
| − | | | + | | {infobox header} | |
|- | |- | ||
|} | |} | ||
[[Category:Tissue transglutaminase|*]] | [[Category:Tissue transglutaminase|*]] | ||
Latest revision as of 11:46, 10 March 2015
| Inter-alpha-inhibitor | |
|---|---|
| Substrate peptide name | Inter-alpha-inhibitor |
| Synonyms | Inter-alpha-trypsin inhibitor |
| Determination type | In vitro |
| Source | Homo sapiens |
| Subcellular localization | Extracellular space |
| Swissprot ID | P19827 - HC1 |
| Reactive glutamines | HC1 - Q8, Q319, Q468
HC2 - Q90, Q203, Q204, Q299, Q315, Q420, Q431, Q438 Bikunin - Q74 |
| Reactive lysines | - |
| Substrate sequence | QAVDTA
SEANLQAAQDF QYYEGS ALAQAR KPTVAQQR VIDFNQNIR TQVADAK NHGIAQR QDTSSQLK FYNQCSTPLLR ECLQTCR |
| Structure | 1BIK |
| Surface accessibility | |
| Disorder prediction | IUPred |
| Reference | PMID:21939789 |
| Notes | Inter-α-inhibitor is cross-linked to the fibrin clot in a 1:20 ratio relative to the known
factor XIIIa substrate α2-antiplasmin. This interaction may protect fibrin or other Lys-donating proteins from adventitious proteolysis by increasing the local concentration of bikunin. |
