Difference between revisions of "Inter-alpha-inhibitor"
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{| class="toccolours" border="1" style="float: left; clear: right; margin: 0 0 1em 1em; border-collapse: collapse;" | {| class="toccolours" border="1" style="float: left; clear: right; margin: 0 0 1em 1em; border-collapse: collapse;" | ||
| − | ! | + | ! {infobox header}| '''{{PAGENAME}}''' |
|- | |- | ||
| Substrate peptide name | | Substrate peptide name | ||
| Line 34: | Line 34: | ||
| Substrate sequence | | Substrate sequence | ||
|''Q''AVDTA | |''Q''AVDTA | ||
| − | SEANL | + | SEANL''Q''AAQDF |
| − | 'Q'YYEGS | + | |
| − | ALA'Q'AR | + | ''Q''YYEGS |
| − | KPTVA'QQ'R | + | |
| − | VIDFN'Q'NIR | + | ALA''Q''AR |
| − | T'Q'VADAK | + | |
| − | NHGIA'Q'R | + | KPTVA''QQ''R |
| − | QDTSS'Q'LK | + | |
| − | FYN'Q'CSTPLLR | + | VIDFN''Q''NIR |
| − | ECL'Q'TCR | + | |
| + | T''Q''VADAK | ||
| + | |||
| + | NHGIA''Q''R | ||
| + | |||
| + | QDTSS''Q''LK | ||
| + | |||
| + | FYN''Q''CSTPLLR | ||
| + | |||
| + | ECL''Q''TCR | ||
|- | |- | ||
| Structure | | Structure | ||
| Line 58: | Line 67: | ||
|- | |- | ||
| Notes | | Notes | ||
| − | | Inter-α-inhibitor is cross-linked to the fibrin clot in a 1:20 ratio relative to the known factor XIIIa substrate α2-antiplasmin. This interaction may protect fibrin or other Lys-donating proteins from adventitious proteolysis by increasing the local concentration of bikunin. | + | | Inter-α-inhibitor is cross-linked to the fibrin clot in a 1:20 ratio relative to the known |
| + | factor XIIIa substrate α2-antiplasmin. This interaction may protect fibrin or other Lys-donating | ||
| + | |||
| + | proteins from adventitious proteolysis by increasing the local concentration of bikunin. | ||
|- | |- | ||
| − | | | + | | {infobox header} | |
|- | |- | ||
|} | |} | ||
[[Category:Tissue transglutaminase|*]] | [[Category:Tissue transglutaminase|*]] | ||
Latest revision as of 11:46, 10 March 2015
| Inter-alpha-inhibitor | |
|---|---|
| Substrate peptide name | Inter-alpha-inhibitor |
| Synonyms | Inter-alpha-trypsin inhibitor |
| Determination type | In vitro |
| Source | Homo sapiens |
| Subcellular localization | Extracellular space |
| Swissprot ID | P19827 - HC1 |
| Reactive glutamines | HC1 - Q8, Q319, Q468
HC2 - Q90, Q203, Q204, Q299, Q315, Q420, Q431, Q438 Bikunin - Q74 |
| Reactive lysines | - |
| Substrate sequence | QAVDTA
SEANLQAAQDF QYYEGS ALAQAR KPTVAQQR VIDFNQNIR TQVADAK NHGIAQR QDTSSQLK FYNQCSTPLLR ECLQTCR |
| Structure | 1BIK |
| Surface accessibility | |
| Disorder prediction | IUPred |
| Reference | PMID:21939789 |
| Notes | Inter-α-inhibitor is cross-linked to the fibrin clot in a 1:20 ratio relative to the known
factor XIIIa substrate α2-antiplasmin. This interaction may protect fibrin or other Lys-donating proteins from adventitious proteolysis by increasing the local concentration of bikunin. |
