Difference between revisions of "Inter-alpha-inhibitor"
m |
m |
||
| (2 intermediate revisions by one other user not shown) | |||
| Line 1: | Line 1: | ||
{| class="toccolours" border="1" style="float: left; clear: right; margin: 0 0 1em 1em; border-collapse: collapse;" | {| class="toccolours" border="1" style="float: left; clear: right; margin: 0 0 1em 1em; border-collapse: collapse;" | ||
| − | ! | + | ! {infobox header}| '''{{PAGENAME}}''' |
|- | |- | ||
| Substrate peptide name | | Substrate peptide name | ||
| Line 35: | Line 35: | ||
|''Q''AVDTA | |''Q''AVDTA | ||
SEANL''Q''AAQDF | SEANL''Q''AAQDF | ||
| + | |||
''Q''YYEGS | ''Q''YYEGS | ||
| Line 66: | Line 67: | ||
|- | |- | ||
| Notes | | Notes | ||
| − | | Inter-α-inhibitor is cross-linked to the fibrin clot in a 1:20 ratio relative to the known factor XIIIa substrate α2-antiplasmin. This interaction may protect fibrin or other Lys-donating proteins from adventitious proteolysis by increasing the local concentration of bikunin. | + | | Inter-α-inhibitor is cross-linked to the fibrin clot in a 1:20 ratio relative to the known |
| + | factor XIIIa substrate α2-antiplasmin. This interaction may protect fibrin or other Lys-donating | ||
| + | |||
| + | proteins from adventitious proteolysis by increasing the local concentration of bikunin. | ||
|- | |- | ||
| − | | | + | | {infobox header} | |
|- | |- | ||
|} | |} | ||
[[Category:Tissue transglutaminase|*]] | [[Category:Tissue transglutaminase|*]] | ||
Latest revision as of 11:46, 10 March 2015
| Inter-alpha-inhibitor | |
|---|---|
| Substrate peptide name | Inter-alpha-inhibitor |
| Synonyms | Inter-alpha-trypsin inhibitor |
| Determination type | In vitro |
| Source | Homo sapiens |
| Subcellular localization | Extracellular space |
| Swissprot ID | P19827 - HC1 |
| Reactive glutamines | HC1 - Q8, Q319, Q468
HC2 - Q90, Q203, Q204, Q299, Q315, Q420, Q431, Q438 Bikunin - Q74 |
| Reactive lysines | - |
| Substrate sequence | QAVDTA
SEANLQAAQDF QYYEGS ALAQAR KPTVAQQR VIDFNQNIR TQVADAK NHGIAQR QDTSSQLK FYNQCSTPLLR ECLQTCR |
| Structure | 1BIK |
| Surface accessibility | |
| Disorder prediction | IUPred |
| Reference | PMID:21939789 |
| Notes | Inter-α-inhibitor is cross-linked to the fibrin clot in a 1:20 ratio relative to the known
factor XIIIa substrate α2-antiplasmin. This interaction may protect fibrin or other Lys-donating proteins from adventitious proteolysis by increasing the local concentration of bikunin. |
