Difference between revisions of "Tau protein"
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| − | ! | + | ! {infobox header}| '''{{PAGENAME}}''' |
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| Substrate peptide name | | Substrate peptide name | ||
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| Synonyms | | Synonyms | ||
| − | | - | + | | Microtubule-associated protein tau |
| + | Neurofibrillary tangle protein | ||
|- | |- | ||
| Determination type | | Determination type | ||
| Line 21: | Line 19: | ||
|- | |- | ||
| Swissprot ID | | Swissprot ID | ||
| − | | [http://au.expasy.org/uniprot/ | + | | [http://au.expasy.org/uniprot/P10636 P10636 ] |
|- | |- | ||
| Reactive glutamines | | Reactive glutamines | ||
| − | | | + | | Q6, Q88, Q124, Q244, Q276, Q288, Q351, '''Q424''' |
|- | |- | ||
| Reactive lysines | | Reactive lysines | ||
| − | | | + | | K24, '''K163, K174, K180, K190, K225, K234, K240''', K383, K385 |
|- | |- | ||
| Substrate sequence | | Substrate sequence | ||
| − | | | + | | MAEPR''Q''EFEVM, GLGDR''K''DQGGY, |
| + | GAPGK''Q''AAAQP, | ||
| + | AGHVT''Q''ARMVS, | ||
| + | APPGQ''K''GQANA, | ||
| + | TRIPA''K''TPPAP''K''TPPSS, | ||
| + | TREPK''K''VAVVR, | ||
| + | AKSRL''Q''TAPVP, | ||
| + | GGGKV''Q''IINKK, | ||
| + | DLSNV''Q''SKCGS, | ||
| + | FKDRV''Q''SKIGS, | ||
| + | FRENA''K''A''K''TDHGA, | ||
| + | MVDSP''Q''LATLA | ||
|- | |- | ||
| Structure | | Structure | ||
| − | | [http://www.rcsb.org/pdb/explore/explore.do?structureId= | + | | [http://www.rcsb.org/pdb/explore/explore.do?structureId=1I8H 1I8H] |
|- | |- | ||
| Surface accessibility | | Surface accessibility | ||
| − | | | + | | |
|- | |- | ||
| Disorder prediction | | Disorder prediction | ||
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| Reference | | Reference | ||
| − | | [http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&list_uids= | + | | [http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&list_uids=9832162&dopt=Abstract PMID:9832162] |
| + | [http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&list_uids=11154823&dopt=Abstract PMID:11154823] | ||
|- | |- | ||
| Notes | | Notes | ||
| − | | | + | | Bold indicates the predominant substrate sites for TG2. |
| + | |||
| + | Upon TG2 action the protein becomes less susceptible to μ-calpain mediated proteolysis. | ||
|- | |- | ||
| − | | | + | | {infobox header} | |
|- | |- | ||
|} | |} | ||
[[Category:Tissue transglutaminase|*]] | [[Category:Tissue transglutaminase|*]] | ||
Latest revision as of 11:58, 10 March 2015
| Tau protein | |
|---|---|
| Substrate peptide name | Tau protein |
| Synonyms | Microtubule-associated protein tau
Neurofibrillary tangle protein |
| Determination type | In situ |
| Source | Homo sapiens |
| Subcellular localization | Cytoskeleton |
| Swissprot ID | P10636 |
| Reactive glutamines | Q6, Q88, Q124, Q244, Q276, Q288, Q351, Q424 |
| Reactive lysines | K24, K163, K174, K180, K190, K225, K234, K240, K383, K385 |
| Substrate sequence | MAEPRQEFEVM, GLGDRKDQGGY,
GAPGKQAAAQP, AGHVTQARMVS, APPGQKGQANA, TRIPAKTPPAPKTPPSS, TREPKKVAVVR, AKSRLQTAPVP, GGGKVQIINKK, DLSNVQSKCGS, FKDRVQSKIGS, FRENAKAKTDHGA, MVDSPQLATLA |
| Structure | 1I8H |
| Surface accessibility | |
| Disorder prediction | IUPred |
| Reference | PMID:9832162 |
| Notes | Bold indicates the predominant substrate sites for TG2.
Upon TG2 action the protein becomes less susceptible to μ-calpain mediated proteolysis. |
