Difference between revisions of "Coagulation factor XIII A chain"

From MyMediaWiki
Jump to: navigation, search
m
 
(8 intermediate revisions by the same user not shown)
Line 1: Line 1:
{| class="toccolours" border="1" style="float: left; clear: right; margin: 0 0 1em 1em; border-collapse: collapse;"
+
{| class="toccolours" border="1" style="float: left; clear: right; margin: 0 0 1em 1em; border-collapse: collapse;" {infobox header}| '''{{Coagulation factor XIII A chain}}'''  
! {{infobox header}}| '''{{PAGENAME}}'''  
 
|-
 
| align="center" colspan="2" bgcolor="#ffffff" | [[Image:Actin.JPG|200px|{{PAGENAME}}]]
 
 
|-
 
|-
 
| Substrate peptide name
 
| Substrate peptide name
| Actin
+
| Coagulation factor XIII A chain
 
|-
 
|-
 
| Synonyms
 
| Synonyms
Line 11: Line 8:
 
|-
 
|-
 
| Determination type
 
| Determination type
| In situ
+
| In vitro
 
|-
 
|-
 
| Source
 
| Source
Line 17: Line 14:
 
|-
 
|-
 
| Subcellular localization
 
| Subcellular localization
| Cytoskeleton
+
| Cytoplasm, Secreted
 
|-
 
|-
 
| Swissprot ID
 
| Swissprot ID
| [http://au.expasy.org/uniprot/P08865 P08865]
+
| [http://au.expasy.org/uniprot/P00488 P00488]
 
|-
 
|-
 
| Reactive glutamines
 
| Reactive glutamines
| [[TG2 reactive residues (Actin)|Q41]]
+
| [[TG2 reactive residues (Coagulation factor XIII A chain)|Q8]]
 
|-
 
|-
 
| Reactive lysines
 
| Reactive lysines
| [[TG2 reactive residues (Actin)|K113]]
+
| -
 
|-
 
|-
 
| Substrate sequence
 
| Substrate sequence
| GRPRH''Q''GVMVG
+
|  
APLNP''K''ANREK
 
 
|-
 
|-
 
| Structure
 
| Structure
| [http://www.rcsb.org/pdb/explore/explore.do?structureId=2BTF 2BTF]
+
| [http://www.rcsb.org/pdb/explore/explore.do?structureId=1GGT 1GGT]
 
|-
 
|-
 
| Surface accessibility
 
| Surface accessibility
 
|  
 
|  
[http://gibk21.bse.kyutech.ac.jp/asaview/all/2btfA.pdf ASAView] pdf
 
[http://gibk21.bse.kyutech.ac.jp/asaview/all/2btfA.txt ASAView] txt
 
 
|-
 
|-
 
| Disorder prediction
 
| Disorder prediction
| [http://iupred.enzim.hu/index.html IUPred]
+
|  
 
|-
 
|-
 
| Reference
 
| Reference
| [http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&list_uids=6892787&dopt=Abstract PMID:6892787]
+
| [http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&list_uids=24443567&dopt=Abstract PMID:24443567]
 
|-
 
|-
 
| Notes
 
| Notes
| There was shown that the FXIIIa catalyzes
+
| Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot.
the polymerization of actin
 
 
|-
 
|-
 
| Video
 
| Video
|{{#ev:youtube|y4WT_bMcQEs|100}}
+
|
|-
 
| {{infobox header}} |  
 
 
|-
 
|-
 +
|
 
|}
 
|}
  
 
[[Category:FXIIIa|*]]
 
[[Category:FXIIIa|*]]

Latest revision as of 15:03, 10 March 2015

Substrate peptide name Coagulation factor XIII A chain
Synonyms -
Determination type In vitro
Source Homo sapiens
Subcellular localization Cytoplasm, Secreted
Swissprot ID P00488
Reactive glutamines Q8
Reactive lysines -
Substrate sequence
Structure 1GGT
Surface accessibility
Disorder prediction
Reference PMID:24443567
Notes Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot.
Video