Difference between revisions of "Inter-alpha-inhibitor"
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| Substrate peptide name | | Substrate peptide name | ||
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| Notes | | Notes | ||
| Inter-α-inhibitor is cross-linked to the fibrin clot in a 1:20 ratio relative to the known | | Inter-α-inhibitor is cross-linked to the fibrin clot in a 1:20 ratio relative to the known | ||
| − | factor XIIIa substrate α2-antiplasmin. This interaction may protect fibrin or other Lys-donating | + | factor XIIIa substrate α2-antiplasmin. This interaction may protect fibrin or other Lys-donating |
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proteins from adventitious proteolysis by increasing the local concentration of bikunin. | proteins from adventitious proteolysis by increasing the local concentration of bikunin. | ||
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| − | | | + | | {infobox header} | |
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[[Category:Tissue transglutaminase|*]] | [[Category:Tissue transglutaminase|*]] | ||
Latest revision as of 11:46, 10 March 2015
| Inter-alpha-inhibitor | |
|---|---|
| Substrate peptide name | Inter-alpha-inhibitor |
| Synonyms | Inter-alpha-trypsin inhibitor |
| Determination type | In vitro |
| Source | Homo sapiens |
| Subcellular localization | Extracellular space |
| Swissprot ID | P19827 - HC1 |
| Reactive glutamines | HC1 - Q8, Q319, Q468
HC2 - Q90, Q203, Q204, Q299, Q315, Q420, Q431, Q438 Bikunin - Q74 |
| Reactive lysines | - |
| Substrate sequence | QAVDTA
SEANLQAAQDF QYYEGS ALAQAR KPTVAQQR VIDFNQNIR TQVADAK NHGIAQR QDTSSQLK FYNQCSTPLLR ECLQTCR |
| Structure | 1BIK |
| Surface accessibility | |
| Disorder prediction | IUPred |
| Reference | PMID:21939789 |
| Notes | Inter-α-inhibitor is cross-linked to the fibrin clot in a 1:20 ratio relative to the known
factor XIIIa substrate α2-antiplasmin. This interaction may protect fibrin or other Lys-donating proteins from adventitious proteolysis by increasing the local concentration of bikunin. |
