Difference between revisions of "Annexin I"
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| − | ! | + | ! {infobox header}| '''{{PAGENAME}}''' |
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| − | | align="center" colspan="2" bgcolor="#ffffff" | [[Image: | + | | align="center" colspan="2" bgcolor="#ffffff" | [[Image:annexin.JPG|200px|{{PAGENAME}}]] |
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| Substrate peptide name | | Substrate peptide name | ||
| Line 9: | Line 8: | ||
|- | |- | ||
| Synonyms | | Synonyms | ||
| − | | | + | | Lipocortin I |
|- | |- | ||
| Determination type | | Determination type | ||
| − | | In situ | + | | In situ/In vitro |
|- | |- | ||
| Source | | Source | ||
| Line 18: | Line 17: | ||
|- | |- | ||
| Subcellular localization | | Subcellular localization | ||
| − | | | + | | Cytosol; the rise of intracellular Ca2+ level causes it’s translocation to plasma membrane |
|- | |- | ||
| Swissprot ID | | Swissprot ID | ||
| − | | [http://au.expasy.org/uniprot/ | + | | [http://au.expasy.org/uniprot/P04083 P04083 ] |
|- | |- | ||
| Reactive glutamines | | Reactive glutamines | ||
| − | | [[ | + | | [[TG2 reactive residues (Annexin I)|Q19]] |
|- | |- | ||
| Reactive lysines | | Reactive lysines | ||
| − | | | + | | [[TG2 reactive residues (Annexin I)|K29]] |
|- | |- | ||
| Substrate sequence | | Substrate sequence | ||
| − | | | + | | IENEE''Q''EYVQT |
| + | |||
| + | TVKSS''K''GGPGS* | ||
| + | |||
|- | |- | ||
| Structure | | Structure | ||
| − | | [http://www.rcsb.org/pdb/explore/explore.do?structureId= | + | | [http://www.rcsb.org/pdb/explore/explore.do?structureId=1HM6 1HM6] |
|- | |- | ||
| Surface accessibility | | Surface accessibility | ||
| − | | [http://gibk21.bse.kyutech.ac.jp/asaview/all/ | + | | [http://gibk21.bse.kyutech.ac.jp/asaview/all/1hm6A.pdf ASAView] pdf |
| + | [http://gibk21.bse.kyutech.ac.jp/asaview/all/1hm6A.txt ASAView] txt | ||
|- | |- | ||
| Disorder prediction | | Disorder prediction | ||
| Line 42: | Line 45: | ||
|- | |- | ||
| Reference | | Reference | ||
| − | | [http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&list_uids= | + | | [http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&list_uids=1670773&dopt=Abstract PMID:1670773] |
|- | |- | ||
| Notes | | Notes | ||
| − | | | + | | * The lysine donor residue is located between residues 1-29 at the N-terminus and probably between residues 27-29. |
| + | |||
| + | Upon crosslinking by TG2 it has higher calcium sensitivity for phospholipid binding. | ||
| + | |||
| + | |- | ||
| + | | Video | ||
| + | |{{#ev:dailymotion|AYK472KQkuLTGkRpA|300}} | ||
|- | |- | ||
| − | | | + | | {infobox header} | |
|- | |- | ||
|} | |} | ||
[[Category:Tissue transglutaminase|*]] | [[Category:Tissue transglutaminase|*]] | ||
Latest revision as of 11:05, 10 March 2015
| Annexin I | |
|---|---|
| |
| Substrate peptide name | Annexin I |
| Synonyms | Lipocortin I |
| Determination type | In situ/In vitro |
| Source | Homo sapiens |
| Subcellular localization | Cytosol; the rise of intracellular Ca2+ level causes it’s translocation to plasma membrane |
| Swissprot ID | P04083 |
| Reactive glutamines | Q19 |
| Reactive lysines | K29 |
| Substrate sequence | IENEEQEYVQT
TVKSSKGGPGS* |
| Structure | 1HM6 |
| Surface accessibility | ASAView pdf
ASAView txt |
| Disorder prediction | IUPred |
| Reference | PMID:1670773 |
| Notes | * The lysine donor residue is located between residues 1-29 at the N-terminus and probably between residues 27-29.
Upon crosslinking by TG2 it has higher calcium sensitivity for phospholipid binding. |
| Video | AYK472KQkuLTGkRpA|300}} |
