Difference between revisions of "S100A11 (TG2)"
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| − | | align="center" colspan="2" bgcolor="#ffffff" | [[Image: | + | | align="center" colspan="2" bgcolor="#ffffff" | [[Image:S100A11.JPG|200px|{{PAGENAME}}]] |
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| Substrate peptide name | | Substrate peptide name | ||
| − | | | + | | S100A11 |
|- | |- | ||
| Synonyms | | Synonyms | ||
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| Reactive glutamines | | Reactive glutamines | ||
| − | | [[ | + | | [[TG2 reactive residues (S100A11)|Q102]] |
|- | |- | ||
| Reactive lysines | | Reactive lysines | ||
| − | | | + | | K3 |
|- | |- | ||
| Substrate sequence | | Substrate sequence | ||
| Line 49: | Line 49: | ||
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| Notes | | Notes | ||
| − | | | + | |Transamidation by TG2 transforms S100A11 into a covalently bonded homodimer |
| + | |||
| + | that acquires the capacity to signal through the p38 MAPK pathway, accelerate | ||
| + | |||
| + | chondrocyte hypertrophy and matrix catabolism. | ||
| + | |- | ||
| + | |Video | ||
| + | |{{#ev:dailymotion|1qxapT72gvd7lkY0F|300}} | ||
|- | |- | ||
| − | | | + | | {infobox header} | |
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[[Category:Tissue transglutaminase|*]] | [[Category:Tissue transglutaminase|*]] | ||
Latest revision as of 11:55, 10 March 2015
| S100A11 (TG2) | |
|---|---|
| |
| Substrate peptide name | S100A11 |
| Synonyms | S100 calcium-binding protein A11
Calgizzarin |
| Determination type | In situ/In vitro |
| Source | Homo sapiens |
| Subcellular localization | Cytosol
Keratinocyte cornified envelope |
| Swissprot ID | P31949 |
| Reactive glutamines | Q102 |
| Reactive lysines | K3 |
| Substrate sequence | KAVPSQKRT
MASKISSPT |
| Structure | 1QLS |
| Surface accessibility | ASAView pdf
ASAView txt |
| Disorder prediction | IUPred |
| Reference | PMID:9446578 |
| Notes | Transamidation by TG2 transforms S100A11 into a covalently bonded homodimer
that acquires the capacity to signal through the p38 MAPK pathway, accelerate chondrocyte hypertrophy and matrix catabolism. |
| Video | 1qxapT72gvd7lkY0F|300}} |
