Difference between revisions of "Tau protein"
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Upon TG2 action the protein becomes less susceptible to μ-calpain mediated proteolysis. | Upon TG2 action the protein becomes less susceptible to μ-calpain mediated proteolysis. | ||
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[[Category:Tissue transglutaminase|*]] | [[Category:Tissue transglutaminase|*]] | ||
Latest revision as of 11:58, 10 March 2015
| Tau protein | |
|---|---|
| Substrate peptide name | Tau protein |
| Synonyms | Microtubule-associated protein tau
Neurofibrillary tangle protein |
| Determination type | In situ |
| Source | Homo sapiens |
| Subcellular localization | Cytoskeleton |
| Swissprot ID | P10636 |
| Reactive glutamines | Q6, Q88, Q124, Q244, Q276, Q288, Q351, Q424 |
| Reactive lysines | K24, K163, K174, K180, K190, K225, K234, K240, K383, K385 |
| Substrate sequence | MAEPRQEFEVM, GLGDRKDQGGY,
GAPGKQAAAQP, AGHVTQARMVS, APPGQKGQANA, TRIPAKTPPAPKTPPSS, TREPKKVAVVR, AKSRLQTAPVP, GGGKVQIINKK, DLSNVQSKCGS, FKDRVQSKIGS, FRENAKAKTDHGA, MVDSPQLATLA |
| Structure | 1I8H |
| Surface accessibility | |
| Disorder prediction | IUPred |
| Reference | PMID:9832162 |
| Notes | Bold indicates the predominant substrate sites for TG2.
Upon TG2 action the protein becomes less susceptible to μ-calpain mediated proteolysis. |
