Difference between revisions of "Inter-alpha-inhibitor"
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| Substrate sequence | | Substrate sequence | ||
| − | | | + | |"Q"AVDTA |
| − | + | SEANL"Q"AAQDF | |
| − | 'Q' | + | 'Q'YYEGS |
ALA'Q'AR | ALA'Q'AR | ||
| − | + | KPTVA'QQ'R | |
| − | + | VIDFN'Q'NIR | |
| − | T'Q' | + | T'Q'VADAK |
| − | + | NHGIA'Q'R | |
| − | + | QDTSS'Q'LK | |
FYN'Q'CSTPLLR | FYN'Q'CSTPLLR | ||
ECL'Q'TCR | ECL'Q'TCR | ||
Revision as of 09:02, 28 September 2011
| Template:Infobox header| Inter-alpha-inhibitor | |
|---|---|
| Substrate peptide name | Inter-alpha-inhibitor |
| Synonyms | Inter-alpha-trypsin inhibitor |
| Determination type | In vitro |
| Source | Homo sapiens |
| Subcellular localization | Extracellular space |
| Swissprot ID | P19827 - HC1 |
| Reactive glutamines | HC1 - Q8, Q319, Q468
HC2 - Q90, Q203, Q204, Q299, Q315, Q420, Q431, Q438 Bikunin - Q74 |
| Reactive lysines | - |
| Substrate sequence | "Q"AVDTA
SEANL"Q"AAQDF 'Q'YYEGS ALA'Q'AR KPTVA'QQ'R VIDFN'Q'NIR T'Q'VADAK NHGIA'Q'R QDTSS'Q'LK FYN'Q'CSTPLLR ECL'Q'TCR |
| Structure | 1BIK |
| Surface accessibility | |
| Disorder prediction | IUPred |
| Reference | PMID:21939789 |
| Notes | Inter-α-inhibitor is cross-linked to the fibrin clot in a 1:20 ratio relative to the known factor XIIIa substrate α2-antiplasmin. This interaction may protect fibrin or other Lys-donating proteins from adventitious proteolysis by increasing the local concentration of bikunin. |
| Template:Infobox header | |
