Difference between revisions of "Tau protein"

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Revision as of 09:09, 25 July 2007

Template:Infobox header| Tau protein
Tau protein
Substrate peptide name Tau protein
Synonyms Microtubule-associated protein tau

Neurofibrillary tangle protein

Determination type In situ
Source Homo sapiens
Subcellular localization Cytoskeleton
Swissprot ID P10636
Reactive glutamines Q6, Q88, Q124, Q244, Q276, Q288, Q351, Q424
Reactive lysines K24, K163, K174, K180, K190, K225, K234, K240, K383, K385
Substrate sequence MAEPRQEFEVM, GLGDRKDQGGY,

GAPGKQAAAQP, AGHVTQARMVS, APPGQKGQANA, TRIPAKTPPAPKTPPSS, TREPKKVAVVR, AKSRLQTAPVP, GGGKVQIINKK, DLSNVQSKCGS, FKDRVQSKIGS, FRENAKAKTDHGA, MVDSPQLATLA

Structure 1I8H
Surface accessibility
Disorder prediction IUPred
Reference PMID:9832162

PMID:11154823

Notes Bold indicates the predominant substrate sites for TG2.

Upon TG2 action the protein becomes less susceptible to μ-calpain mediated proteolysis.

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