Difference between revisions of "Inter-alpha-inhibitor (FXIIIa)"
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proteins from adventitious proteolysis by increasing the local concentration of bikunin. | proteins from adventitious proteolysis by increasing the local concentration of bikunin. | ||
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[[Category:FXIIIa|*]] | [[Category:FXIIIa|*]] | ||
Latest revision as of 11:11, 10 March 2015
| Inter-alpha-inhibitor (FXIIIa) | |
|---|---|
| Substrate peptide name | Inter-alpha-inhibitor (FXIIIa) |
| Synonyms | Inter-alpha-trypsin inhibitor |
| Determination type | In vitro |
| Source | Homo sapiens |
| Subcellular localization | Extracellular space |
| Swissprot ID | P19827 - HC1 |
| Reactive glutamines | HC1 - Q8
HC2 - Q90, Q204, Q299, Q315, Q420, Q426, Q431, Q438 Bikunin - Q74 |
| Reactive lysines | - |
| Substrate sequence | QAVDTA
ALAQAR PTVAQQR VIDFNQNIR TQVADAK NHGIAQR IYGNQDTSSQLK FYNQCSTPLLR ECLQTCR |
| Structure | 1BIK |
| Surface accessibility | |
| Disorder prediction | IUPred |
| Reference | PMID:21939789 |
| Notes | Inter-α-inhibitor is cross-linked to the fibrin clot in a 1:20 ratio relative to the known
factor XIIIa substrate α2-antiplasmin. This interaction may protect fibrin or other Lys-donating proteins from adventitious proteolysis by increasing the local concentration of bikunin. |
