Histone octamer (transglutaminase)
| Histone octamer (transglutaminase) | |
|---|---|
| Substrate peptide name | Histone octamer (transglutaminase) |
| Synonyms | Core histone |
| Determination type | In situ/In vitro |
| Source | Homo sapiens
Gallus gallus |
| Subcellular localization | Nuclear |
| Swissprot ID | P04908 |
| Reactive glutamines | H2A – Q24, Q104, Q112
H2B – Q95, Q22 H3 – Q125, Q5, Q19 |
| Reactive lysines | H2B - K116, K125 |
| Substrate sequence | H2A – KVTIAQGGVLPNIQAVLLP
H2B – TSREIQTAVRL H2B - VESEGKAVTKYTSSK H3 - ARTKQTARKS H3 - KAPRKQL H3 - MPKDIQLARRI H4 – LKRQGRTLY |
| Structure | 1TZY |
| Surface accessibility | ASAView pdf |
| Disorder prediction | IUPred |
| Reference | PMID:8702540 |
| Notes | *Residues in bold are TG2 substrates in free core histones; residues in italics (Q22, Q5 and Q19) serve as TG2 substrates in nucleosomes.
Q122 is substrate only at certain temperature |
