Inter-alpha-inhibitor
| Inter-alpha-inhibitor | |
|---|---|
| Substrate peptide name | Inter-alpha-inhibitor |
| Synonyms | Inter-alpha-trypsin inhibitor |
| Determination type | In vitro |
| Source | Homo sapiens |
| Subcellular localization | Extracellular space |
| Swissprot ID | P19827 - HC1 |
| Reactive glutamines | HC1 - Q8, Q319, Q468
HC2 - Q90, Q203, Q204, Q299, Q315, Q420, Q431, Q438 Bikunin - Q74 |
| Reactive lysines | - |
| Substrate sequence | QAVDTA
SEANLQAAQDF QYYEGS ALAQAR KPTVAQQR VIDFNQNIR TQVADAK NHGIAQR QDTSSQLK FYNQCSTPLLR ECLQTCR |
| Structure | 1BIK |
| Surface accessibility | |
| Disorder prediction | IUPred |
| Reference | PMID:21939789 |
| Notes | Inter-α-inhibitor is cross-linked to the fibrin clot in a 1:20 ratio relative to the known
factor XIIIa substrate α2-antiplasmin. This interaction may protect fibrin or other Lys-donating proteins from adventitious proteolysis by increasing the local concentration of bikunin. |
