PTEN

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PTEN
Substrate peptide name PTEN - Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and

dual-specificity protein phosphatase

Synonyms -
Determination type In situ
Source Homo sapiens
Subcellular localization Cytosol
Swissprot ID P60484
Interacting residues Not determined yet
Interacting sequence Not determined yet
TG2 Swissprot ID P21980
Interacting residues of TG2 Not determined yet
Interacting sequence of TG2 Not determined yet
Structure 1D5R
Surface accessibility
Disorder prediction IUPred
Reference PMID:18381937
Notes TG2 promotes the hypophosphorilation and degradation of PTEN by ubiquitin-proteasomal

pathway and results in constitutive activation of focal adhesion kinase/AKT cell survival signaling.