Difference between revisions of "Collagen (TG2)"
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{| class="toccolours" border="1" style="float: left; clear: right; margin: 0 0 1em 1em; border-collapse: collapse;" | {| class="toccolours" border="1" style="float: left; clear: right; margin: 0 0 1em 1em; border-collapse: collapse;" | ||
| − | ! | + | ! {infobox header}| '''{{PAGENAME}}''' |
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|- | |- | ||
| Substrate peptide name | | Substrate peptide name | ||
| − | | | + | | Collagen |
|- | |- | ||
| Synonyms | | Synonyms | ||
| Line 12: | Line 9: | ||
|- | |- | ||
| Determination type | | Determination type | ||
| − | | In | + | | In vitro |
|- | |- | ||
| Source | | Source | ||
| Line 18: | Line 15: | ||
|- | |- | ||
| Subcellular localization | | Subcellular localization | ||
| − | | | + | | Cytosol/Extracellular |
|- | |- | ||
| Swissprot ID | | Swissprot ID | ||
| − | | [http://au.expasy.org/uniprot/ | + | | [http://au.expasy.org/uniprot/P02461 P02461 ] |
| + | [http://au.expasy.org/uniprot/P020908 P020908 ] | ||
| + | [http://au.expasy.org/uniprot/Q02388 Q02388 ] | ||
| + | [http://au.expasy.org/uniprot/P12107 P12107 ] | ||
|- | |- | ||
| Reactive glutamines | | Reactive glutamines | ||
| − | | | + | | III.-Q14 |
| + | |||
| + | proVII.-Q2796, Q2800, Q2805, Q2807* | ||
| + | |||
|- | |- | ||
| Reactive lysines | | Reactive lysines | ||
| Line 30: | Line 33: | ||
|- | |- | ||
| Substrate sequence | | Substrate sequence | ||
| − | | | + | | III.-CSHLG''Q''SYADR |
| + | |||
| + | VII.-RGFVR''Q''EMS''Q''HCAC''Q''G''Q''FIASG* | ||
| + | |||
|- | |- | ||
| Structure | | Structure | ||
| − | | | + | | No available crystal structure |
|- | |- | ||
| Surface accessibility | | Surface accessibility | ||
| − | | | + | | |
|- | |- | ||
| Disorder prediction | | Disorder prediction | ||
| Line 42: | Line 48: | ||
|- | |- | ||
| Reference | | Reference | ||
| − | | [http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&list_uids= | + | | [http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&list_uids=2879837&dopt=Abstract PMID:2879837] |
| + | [http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&list_uids=8787681&dopt=Abstract PMID:8787681] | ||
| + | [http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&list_uids=7577969&dopt=Abstract PMID:7577969] | ||
|- | |- | ||
| Notes | | Notes | ||
| − | | | + | | * These residues are potential TG2 glutamine donor substrates situated on NC-2 domain of procollagen VII. |
| + | |||
| + | The crosslink catalyzed by transglutaminases are important for the protein's physiological functions | ||
| + | |||
|- | |- | ||
| − | | | + | | {infobox header} | |
|- | |- | ||
|} | |} | ||
[[Category:Tissue transglutaminase|*]] | [[Category:Tissue transglutaminase|*]] | ||
Latest revision as of 11:31, 10 March 2015
| Collagen (TG2) | |
|---|---|
| Substrate peptide name | Collagen |
| Synonyms | - |
| Determination type | In vitro |
| Source | Homo sapiens |
| Subcellular localization | Cytosol/Extracellular |
| Swissprot ID | P02461 |
| Reactive glutamines | III.-Q14
proVII.-Q2796, Q2800, Q2805, Q2807* |
| Reactive lysines | Not determined yet |
| Substrate sequence | III.-CSHLGQSYADR
VII.-RGFVRQEMSQHCACQGQFIASG* |
| Structure | No available crystal structure |
| Surface accessibility | |
| Disorder prediction | IUPred |
| Reference | PMID:2879837 |
| Notes | * These residues are potential TG2 glutamine donor substrates situated on NC-2 domain of procollagen VII.
The crosslink catalyzed by transglutaminases are important for the protein's physiological functions |
