Difference between revisions of "Midkine"
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{| class="toccolours" border="1" style="float: left; clear: right; margin: 0 0 1em 1em; border-collapse: collapse;" | {| class="toccolours" border="1" style="float: left; clear: right; margin: 0 0 1em 1em; border-collapse: collapse;" | ||
| − | ! | + | ! {infobox header}| '''{{PAGENAME}}''' |
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| − | | align="center" colspan="2" bgcolor="#ffffff" | [[Image: | + | | align="center" colspan="2" bgcolor="#ffffff" | [[Image:Midkine_N.JPG|200px|Midkine N-terminal part}]][[Image:Midkine_C.JPG|200px|Midkine C-terminal part]] |
|- | |- | ||
| Substrate peptide name | | Substrate peptide name | ||
| Line 9: | Line 8: | ||
|- | |- | ||
| Synonyms | | Synonyms | ||
| − | | - | + | | Neurite outgrowth-promoting protein |
| + | Midgestation and kidney protein | ||
| + | |||
| + | Amphiregulin-associated protein | ||
|- | |- | ||
| Determination type | | Determination type | ||
| − | | In | + | | In vitro |
|- | |- | ||
| Source | | Source | ||
| Line 18: | Line 20: | ||
|- | |- | ||
| Subcellular localization | | Subcellular localization | ||
| − | | | + | | Extracellular, plasma |
|- | |- | ||
| Swissprot ID | | Swissprot ID | ||
| − | | [http://au.expasy.org/uniprot/ | + | | [http://au.expasy.org/uniprot/P21741 P21741 ] |
|- | |- | ||
| Reactive glutamines | | Reactive glutamines | ||
| − | | [[ | + | | [[TG2 reactive residues (Midkine)|Q42, Q44, Q95]] |
|- | |- | ||
| Reactive lysines | | Reactive lysines | ||
| − | | | + | | [[TG2 reactive residues (Midkine)|K63]] |
|- | |- | ||
| Substrate sequence | | Substrate sequence | ||
| − | | | + | | GTCGA''Q''T''Q''RIRCR |
| + | |||
| + | NAQC''Q''ETIRV | ||
| + | |||
| + | FGADC''K''YKFEN | ||
| + | |||
|- | |- | ||
| Structure | | Structure | ||
| − | | [http://www.rcsb.org/pdb/explore/explore.do?structureId= | + | | [http://www.rcsb.org/pdb/explore/explore.do?structureId=1MKN 1MKN] |
| + | [http://www.rcsb.org/pdb/explore/explore.do?structureId=1MKC 1MKC] | ||
|- | |- | ||
| Surface accessibility | | Surface accessibility | ||
| − | | [http://gibk21.bse.kyutech.ac.jp/asaview/all/ | + | | [http://gibk21.bse.kyutech.ac.jp/asaview/all/1mkn.pdf ASAView] pdf |
| + | [http://gibk21.bse.kyutech.ac.jp/asaview/all/1mkn.txt ASAView] txt | ||
| + | |||
| + | [http://gibk21.bse.kyutech.ac.jp/asaview/all/1mkc.pdf ASAView] pdf | ||
| + | |||
| + | [http://gibk21.bse.kyutech.ac.jp/asaview/all/1mkc.txt ASAView] txt | ||
|- | |- | ||
| Disorder prediction | | Disorder prediction | ||
| Line 42: | Line 55: | ||
|- | |- | ||
| Reference | | Reference | ||
| − | | [http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&list_uids= | + | | [http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&list_uids=9083079&dopt=Abstract PMID:9083079] |
| + | [http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&list_uids=9384573&dopt=Abstract PMID:9384573] | ||
|- | |- | ||
| Notes | | Notes | ||
| − | | | + | | It seems that Q42 and Q44 serve alternatively as glutamine donor substrates |
| + | |||
| + | It has enhanced activity upon crosslinking by TG2. | ||
| + | |||
| + | |- | ||
| + | |Video | ||
| + | |{{#ev:dailymotion|2F4D1DzxlUuuMkXSJ|300}} | ||
| + | {{#ev:dailymotion|3hU9k7xBi67hTkXT8|300}} | ||
|- | |- | ||
| − | | | + | | {infobox header} | |
|- | |- | ||
|} | |} | ||
[[Category:Tissue transglutaminase|*]] | [[Category:Tissue transglutaminase|*]] | ||
Latest revision as of 11:47, 10 March 2015
| Midkine | |
|---|---|
 
| |
| Substrate peptide name | Midkine |
| Synonyms | Neurite outgrowth-promoting protein
Midgestation and kidney protein Amphiregulin-associated protein |
| Determination type | In vitro |
| Source | Homo sapiens |
| Subcellular localization | Extracellular, plasma |
| Swissprot ID | P21741 |
| Reactive glutamines | Q42, Q44, Q95 |
| Reactive lysines | K63 |
| Substrate sequence | GTCGAQTQRIRCR
NAQCQETIRV FGADCKYKFEN |
| Structure | 1MKN |
| Surface accessibility | ASAView pdf
ASAView txt ASAView pdf ASAView txt |
| Disorder prediction | IUPred |
| Reference | PMID:9083079 |
| Notes | It seems that Q42 and Q44 serve alternatively as glutamine donor substrates
It has enhanced activity upon crosslinking by TG2. |
| Video | 2F4D1DzxlUuuMkXSJ|300}}
{{#ev:dailymotion|3hU9k7xBi67hTkXT8|300}} |
