Difference between revisions of "Midkine"
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| − | | align="center" colspan="2" bgcolor="#ffffff" | [[Image: | + | | align="center" colspan="2" bgcolor="#ffffff" | [[Image:Midkine_N.JPG|200px|Midkine N-terminal part}]][[Image:Midkine_C.JPG|200px|Midkine C-terminal part]] |
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| Substrate peptide name | | Substrate peptide name | ||
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| Neurite outgrowth-promoting protein | | Neurite outgrowth-promoting protein | ||
Midgestation and kidney protein | Midgestation and kidney protein | ||
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Amphiregulin-associated protein | Amphiregulin-associated protein | ||
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| Reactive glutamines | | Reactive glutamines | ||
| − | | [[ | + | | [[TG2 reactive residues (Midkine)|Q42, Q44, Q95]] |
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| Reactive lysines | | Reactive lysines | ||
| − | | [[ | + | | [[TG2 reactive residues (Midkine)|K63]] |
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| Substrate sequence | | Substrate sequence | ||
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| − | | {{infobox header | + | |Video |
| + | |{{#ev:dailymotion|2F4D1DzxlUuuMkXSJ|300}} | ||
| + | {{#ev:dailymotion|3hU9k7xBi67hTkXT8|300}} | ||
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| + | | {infobox header} | | ||
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[[Category:Tissue transglutaminase|*]] | [[Category:Tissue transglutaminase|*]] | ||
Latest revision as of 11:47, 10 March 2015
| Midkine | |
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| |
| Substrate peptide name | Midkine |
| Synonyms | Neurite outgrowth-promoting protein
Midgestation and kidney protein Amphiregulin-associated protein |
| Determination type | In vitro |
| Source | Homo sapiens |
| Subcellular localization | Extracellular, plasma |
| Swissprot ID | P21741 |
| Reactive glutamines | Q42, Q44, Q95 |
| Reactive lysines | K63 |
| Substrate sequence | GTCGAQTQRIRCR
NAQCQETIRV FGADCKYKFEN |
| Structure | 1MKN |
| Surface accessibility | ASAView pdf
ASAView txt ASAView pdf ASAView txt |
| Disorder prediction | IUPred |
| Reference | PMID:9083079 |
| Notes | It seems that Q42 and Q44 serve alternatively as glutamine donor substrates
It has enhanced activity upon crosslinking by TG2. |
| Video | 2F4D1DzxlUuuMkXSJ|300}}
{{#ev:dailymotion|3hU9k7xBi67hTkXT8|300}} |
